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The cited JAMA studys authors made note of the uncertainty that remains regarding issues such as patient adherence

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Signaling Peptides (Hormones) These regulate metabolic and physiological processes: GLP-1 (glucagon-like peptide-1): appetite and glucose regulation Growth hormone (GH): tissue repair, fat metabolism, recovery Insulin: Controls blood sugar uptake PYY (peptide YY): Signals fullness after eating 2

Retatrutide is an investigational injectable triple agonist targeting GLP-1, GIP, and glucagon receptors, currently in clinical trials for obesity and type 2 diabetes but not yet approved by the MHRA or EMA