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Rybelsus is a GLP-1 receptor agonist that directly targets appetite centres in the hypothalamus and slows gastric emptying

Mark Hyman explains why that doesnt always reflect wellness, and what early signals can be missed over time

The risk and odds ratios were significantly lower in the GLP-1RA-treated cohorts than in DPP-4i across all analyses

Ghrelin receptor activation in the ventral tegmental area amplified instrumental responding but not the excitatory influence of Pavlovian stimuli on instrumental responding

However, obesity is a global health challenge with few drug options (100)
