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Second, cerebrospinal fluid has its own way of passing into the brain

Semaglutide activates only the GLP-1 receptor pathway (not GIPR), which some patients tolerate differently than the dual-pathway stimulation of tirzepatide

These are translationally relevant findings and overall consistent with recent human evidence that suggest a role of the GLP-1 system in alcohol drinking and AUD, as indicated by alcohol administration studies (115, 116), postmortem brain analyses (115), and neuroimaging-genetic investigations (116, 117)

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"Unfortunately, price is what is driving the decision-making between clinicians and patients for these drugs because they're all excellent drugs and we have lots of options now, but it's still a financial decision at the end of the day," Kansal said

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