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Some patients, termed super-responders, lose more weight than expected

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Interestingly, in ex vivo studies from human tissue, the duodenum and ileum but not the colon were found to be glucose responsive (218) which is different than what is reported in mouse colon (178, 191) but are consistent with data where patients that have had colon resection have normal GLP-1 responses to glucose (185)

However, the relationship between BMI and response to biologic therapies is not uniformly consistent across studies