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As shown in Figure 2 , following stimulation of GLP-1R by exenatide on microglia, the cAMP/PKA/p38/CREB signal transduction pathway is activated, promoting the expression of IL-10

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What is GLP-1 Therapy

However, stopping abruptly often triggers rapid appetite rebound, making weight management harder psychologically and behaviorally

18-20 GLP1 receptors are present in the brain, and preclinical studies indicated that even though only small amounts of GLP-1 RAs crossed the blood-brain barrier, they exerted significant antiinflammatory effects