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Metformin, a medication primarily prescribed to help individuals manage their blood sugar levels in cases of type 2 diabetes, has garnered attention for its potential side effect of weight loss

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These GLP-1 medications are initially prescribed at a low dose, which increases over time

These include people with: Personal history of medullary thyroid carcinoma Family history of Multiple Endocrine Neoplasia syndrome type 2 History of severe pancreatitis Severe gastrointestinal disease Your doctor will review your medical history before prescribing any GLP-1 medication

Trials to date have shown that GLP-1s may have beneficial effects on kidney function, especially relevant for T2D patients with chronic kidney disease (CKD)

MECHANISMS OF ACTION OF GLP-1 RAs AND MULTI-AGONIST THERAPIES Incretin-based therapies leverage the physiological roles of gut-derived peptide hormones, principally glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptor (GCG) to address the multifaceted pathophysiology of MASLD