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Hotamisligil GS, Shargill NS, Spiegelman BM

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Fermentation of fibre by gut microbiota produces short-chain fatty acids, which may stimulate GLP-1 release

It is believed that this may be a result of side effects caused by the medication, such as dehydration, blood sugar fluctuations, systemic effects on fluid balance, and inflammation

Notably, recent findings have described the pleiotropic effects of SGLT-2is in terms of cardioprotection as well as renoprotection (1319)

Pregnancy and breastfeeding Insulin is the preferred treatment for diabetes during pregnancy