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The mechanism of heart rate increase with semaglutide is primarily indirect, mediated through autonomic nervous system effects rather than direct cardiac stimulation

Am J Kidney Dis 71(1):6574 Tonneijck L, Muskiet MHA, Smits MM, van Bommel EJ, Heerspink HJL, van Raalte DH et al (2017) Glomerular hyperfiltration in diabetes: mechanisms, clinical significance, and treatment

GLP-1 agonists have emerged as promising therapeutic agents for diabetic cardiomyopathy through multiple protective mechanisms

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