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Patients Lost 31LBS on Average In a trial with 1,387 patients who were obese but did not have Type 2 diabetes, patients were randomly assigned to different doses of Semaglutide

The additive effect is still present, but the mechanistic diversity is somewhat narrower

Last reviewed: May 18, 2026 Last updated: May 18, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

These biomarkers include leptin, chitinase-3 like-protein-1 (YKL-40), growth differentiation factor 15 (GDF-15), and intercellular adhesion molecule 1 (ICAM-1)

To conduct the PSA, we used a simultaneous sampling approach for all distribution parameters

Stopping abruptly is the recommended approach