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Three new Cochrane reviews find evidence that GLP-1 drugs result in clinically meaningful weight loss, but industry-funded studies raise questions.

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Here we investigate this problem in the nematode gonad, where germline stem cells are maintained by Notch signaling from the niche and PUF RNA binding proteins in stem cells

Methods We administered male rats with intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) GLP-1R agonist (exendin-4) or antagonist (exendin-9-39) followed by in vivo determination of CSF dynamics

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