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The pathogenesis originates from an imbalance in hepatic lipid homeostasis, where excessive triglyceride accumulation results from increased lipid influx, enhanced de novo lipogenesis, and impaired lipid export or oxidation
The cuprizone (Cup) model in mice induces highly reproducible demyelination of distinct brain regions, among them the corpus callosum (CC) [121]
In people with established CVD, a GLP-1 RA with proven benefit should be used to reduce MACE, or an SGLT2i with proven benefit should be used to reduce MACE and HF and improve kidney outcomes
Urinary samples of a mouse model for diabetic nephropathy (GIPRdn) 32 (n = 3 mice) serves as positive control (g)
