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However, definitive evidence from adequately powered human trials demonstrating cognitive benefits is still lacking, and ongoing phase 3 studies are investigating these potential effects

Holst JJ, Buse JB, Rodbard HW, Linjawi S, Woo VC, Boesgaard TW, et al

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Disproportionality analysis A sequential approach was adopted to systematically address major confounders: (1) An exploratory disproportionality approach comparing GLP-1RAs with all other drugs reported in the FAERS database, using venlafaxine as the positive control and empagliflozin/orlistat as the negative control

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Tirzepatide targets both GLP-1 and another incretin receptor called GIP