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Clinical evidence: key trials and outcomes The kidney-protective potential of SGLT2 inhibitors was first identified in cardiovascular outcome trials, including Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus PatientsRemoving Excess Glucose (EMPA-REG OUTCOME) [36], Canagliflozin Cardiovascular Assessment Study (CANVAS) [37], and Dapagliflozin Effect on Cardiovascular EventsThrombolysis in Myocardial Infarction 58 (DECLARETIMI 58) [38]

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According to Egan, it took the brand one year to develop and when it launched, it far exceeded the team's expectations, ultimately leading to a significant pivot for the company

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Retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously, is advancing through clinical trials and may offer even more pronounced anti-inflammatory and metabolic effects than current options

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