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In a pilot trial evaluating 104 amnestic MCI and early-stage AD patients, 20 IU and 40 IU doses of intranasal insulin improved Alzheimers Disease Assessment Scale-Cognitive subscale (ADAS-Cog 12) scores compared to placebo-treated patients, with improvements in delayed recall observed 2 months following cessation of treatment in the 20 IU group
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Anti-inflammatory mechanism at low doses The anti-inflammatory effects of GLP-1R agonism are not dose-dependent in the same way that weight loss is

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On-target effects of GLP-1 receptor agonists on thyroid C-cells in rats and mice
