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![Figure][1] ### Competing Interest Statement The authors have declared no competing interest

Discontinuation due to adverse events was 11.3% at the highest dose versus 4.9% on placebo

3 Global development is accelerating Kailera also presented the first ribupatide injection data generated outside China

GLP-1 (Glucagon-Like Peptide-1) agonists work by: Increasing insulin secretion Delaying gastric emptying Reducing appetite via central mechanisms The result

Our objectives were to compare incretin concentrations and rates of glucose production and gluconeogenesis in youth with type 2 diabetes before and after short-term metformin therapy compared with peers with normal glucose tolerance (NGT)