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A supervised team matters because these are powerful prescription tools, not over-the-counter products

The single-arm observational design and lack of a control group limit causal inference and make it difficult to distinguish drug-related effects from natural disease fluctuations or lifestyle changes

Ann Intern Med 157:373378

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Study participants either had rheumatoid arthritis or spondyloarthritis

Women who become pregnant during a clinical trial should discontinue treatment immediately and inform their trial team