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B12 deficiency becomes more common on GLP-1 therapy, so some patients benefit from monthly B12 injections or sublingual supplements in addition to a standard multivitamin

Heart rate increases were also noted at higher doses of retatrutide, another effect potentially linked to glucagon-mediated increases in metabolic rate

Last reviewed: May 15, 2026 Last updated: May 15, 2026 Written by: Jay Hastings , CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Over time, this persistent inflammatory state damages tissues, impairs organ function, and even erodes cognitive health, setting the stage for age-related diseases such as diabetes, cardiovascular disease, neurodegeneration, and cancer

Patient comes in and says, look, I saw X, Y, and Z celebrity, certain tennis player or somebody else, certain TV hosts, I wont mention any names, but I saw somebody and they lost all this weight

AN is more common in type 2 diabetes mellitus (2) and is more prevalent in those with darker skin color