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GLP-1 drugs such as Ozempic, Wegovy, and Mounjaro were initially developed to treat type 2 diabetes, but their effectiveness as anti-obesity medications has generated tremendous excitement and high demand among people who have struggled to lose weight by other means

Post-market reportswhich may overestimate side effectshave noted renal impairment upon initiation and dose escalation of GLP-1s, possibly due to dehydration from nausea and vomiting [115]

Pharmaceutical companies already at the forefront of GLP-1RA development have benefitted from this, while others are making significant investments to enter the weight-loss drugs market

French physiologist Jean La Barre first used the term incretine in 1932 to describe a substance which lowered glucose levels by augmenting insulin release and actions.4 5 We now know that GLP-1 and glucose-dependent insulinotropic peptide (GIP) are the two main incretin hormones

This is reassuring, but the data in humans is still limited, and larger studies are needed to fully understand how these medications affect fertility and pregnancy (12,13)

Some patients needed hospital care due to dosing mistakes with compounded injectable semaglutide products [21]