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The medication's effects on central appetite regulation occur through both peripheral and central nervous system pathways, which becomes relevant when considering neurological symptoms such as cognitive changes

Other considerations include individuals with gastrointestinal issues, as semaglutide may cause nausea, vomiting, or diarrhea, especially during the initial stages of treatment

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Patients should never increase their dose more rapidly than prescribed, even if they feel they are tolerating the current dose well

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The two agents may be started simultaneously or sequentially , depending on clinical circumstances and patient factors