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Recommendations for practical use of Metformin, a central pharmacological therapy in type 2 diabetes

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Biological actions of the incretins GIP and GLP-1 and therapeutic perspectives in patients with type 2 diabetes

Wing RR, Bolin P, Bracanti FL et al

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1 , 2 Constipation is reported in 4% to 12% of patients and occurs more frequently in individuals with obesity, likely due to the use of higher doses