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Diabetes Journals+1 Neuroinflammation / oxidative stress : GLP-1 agents appear to reduce microglial activation, lower inflammatory cytokines, improve antioxidant defenses in brain tissue

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The exact mechanism by which metformin can contribute to lactic acidosis has yet to be fully understood [199]

pmid:26757772

Moreover, the Summary of Product Characteristics on the Electronic Medicines Compendium states that Therapeutic experience in patients 75 years of age is limited

This causes more trauma to the injection site