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Thus, creating a void to conduct future studies to examine longer duration treatment to check their prolonged effects (98)

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More recently, novel formulations of double and triple gut hormone receptor agonists (involving glucose-dependent insulinotropic polypeptide [GIP] and glucagon) have been successfully developed [4], and other hormones, such as oestrogens and thyroid hormones, have also shown potential for use as therapies for the treatment of diabetes

Treatment with exenatide increased insulin signaling pathway activity, AMPK signaling pathway activation, and lipid oxidation enzyme stimulation [73]