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The results of our analysis confirm the lack of any benefit by DPP-4 inhibitors on cardiorenal outcomes in people with type 2 diabetes [22]
doi:10.1074/jbc.M510414200 27

This result suggests a baseline dependence on EGFR to respond to a glucose load
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Figure 4 shows the results of SURPASS-4 by tirzepatide dose as well as for all doses pooled, compared to insulin glargine treatment

Significant fluctuations, if not well-controlled, can lead to diabetic retinopathy
