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The most commonly reported adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation, rather than neurological pain syndromes

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The data is clear: participants who started at higher doses or escalated too quickly had nearly double the gastrointestinal side effects compared to those who titrated gradually

Since these receptors are present in various organ systems and in the brain, their roles in satiety and appetite regulation, as well as neuroinflammation and neuroplasticity, must be considered

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This demands more frequent engagement but avoids injections entirely