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Discussion In this systematic review and meta-analysis we summarised and synthesised the most up-to-date data from RCTs of once-weekly tirzepatide in individuals with type 2 diabetes

In particular, the discovery of GLP-1 receptors in cardiovascular tissues opened new therapeutic possibilities beyond glycemic control

This does not mean the medication was a failure

The combined GLP-1/GIP profile is what gives tirzepatide its edge over semaglutide

Insurance coverage remains inconsistent, with many plans excluding weight loss indications entirely
