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Notably, currently approved GLP-1RAs such as semaglutide, exenatide, dulaglutide, and liraglutide are known to cross the bloodbrain barrier (BBB), thereby gaining access to the CNS [39,40]

Staying on 0.25mg long-term often leads to a weight loss plateau around 5 to 8 pounds because your body adapts to the appetite suppression

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