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In T2DM with obesity, adipose tissue becomes dysfunctionalcharacterized by adipocyte hypertrophy, altered extracellular matrix (ECM) remodeling, immune cell infiltration, and impaired mitochondrial functionthereby promoting insulin resistance and systemic metabolic deterioration [1]

People in the maintenance phase The ATTAIN-MAINTAIN data specifically supports using orforglipron after achieving weight loss with injectable medications

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