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Most researchers notice subtle appetite changes within the first week, though some feel nothing at the starting dose

Blood in urine : Hematuria always requires investigation to exclude infection, kidney stones, or more serious urological conditions

Common side effects include nausea, vomiting, diarrhea, stomach pain, and constipation, similar to those experienced with injectable tirzepatide

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The most common adverse effects of semaglutide include nausea (occurring in up to 44% of patients on Wegovy's highest dose), vomiting, diarrhea, abdominal pain, and constipation

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