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Although functional data supporting a trans- inhibition model were obtained when constitutive activation of JAK2 was shown with a JAK2 construct where the pseudokinase and KDs were swapped and this construct showed significant cytokine-independent activation only in the presence of wild-type JAK2 (51)

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doi: 10.1093/oxfordjournals.pcp.a076232 45 NavabpourS.YamchiA.BagherikiaS.KafiH

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