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Stimulators (agonists) of the GLP-1 receptor have gained widespread attention for their effects on brain pathways involved in appetite regulation and reward
Clinical trials have shown that GLP-1R agonists increase microvascular blood volume and flow in cardiac muscle, and these effects are preserved in obese individuals with vascular insulin resistance
doi: 10.1172/jci.insight.153732
Indeed, a meta-analysis by Nreu et al
Lilly reported that patients on retatrutide lost a large average percentage of body weight, and some patients moved below the obesity range
