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It typically affects both sides of the body symmetrically and stops at the wrists or ankles

Retatrutide (LY3437943) is a synthetic triple incretin peptide targeting GLP-1, GIP, and glucagon receptors

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Finally, in contrast to the lean mass loss that occurs with GLP-1 medications, ketogenic diets have been shown to help preserve muscle mass during weight loss.(12) Keeping the Weight Off with Keto After Stopping GLP- 1 Medication Although GLP-1 medications are effective for weight loss, their high cost and risks of significant muscle loss and weight regain emphasize the need for alternative approaches

Sitagliptin (Januvia) is more likely to cause skin reactions, including bullous pemphigoid

Reinhardt C, Reigstad CS, Backhed F