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In a meta-analysis of large clinical trials investigating the cardiorenal benefits of GLP-1R agonists in T2D, there was a trend towards reduction of reported pulmonary adverse events in the GLP-1R agonist treatment groups [10]
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In a systematic review by He et al., pooling data from 76 randomized controlled trials, it was observed that individuals receiving GLP-1RAs had a 37% higher relative risk of developing gallbladder disease compared with those not receiving them, with a marked increase in cases of cholelithiasis and cholecystitis
Some healthcare providers prescribe split dosing, dividing the weekly amount into two doses given three to four days apart
