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doi: 10.1111/dom.16366

The FDAs updated label now highlights the risk of ileus, a condition where the intestines cannot move food properly, which can lead to severe blockages

Even some refrigerators, particularly older models or those set too cold, can create localized freezing conditions

GLP-1RAs and osteoclasts The greater degree of bone degradation observed in mice lacking GLP-1R indicates that GLP-1R signaling suppresses osteoclast differentiation and bone resorption

And research published in JCI Insight reveals something fascinating: tirzepatide shows an "imbalanced" affinity, engaging GIP receptors more strongly than GLP-1 receptors while producing biased signaling at the GLP-1 receptor that favors cAMP generation over beta-arrestin recruitment