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Conclusion 4-8: Stratifying populations in a meaningful way using precision medicine approaches and applying this level of resolution to the prevention and treatment of AD/ADRD will require investment in exploratory research, neuroimaging and multiomics approaches, and computational tools and analytics to elucidate determinants of AD/ADRD risk and variability of response to interventions in diverse populations

This exceptionally high enzyme stability of the bicyclic and tricyclic GLP-1 analogs would be of interest in achieving a long-acting in vivo activity and molecular imaging of pancreatic -cells via the GLP-1 receptor (vide infra)

Certain groups may require modifications based on physiological differences that affect drug metabolism, tolerance, or risk profile

Emerging research indicates that following COVID-19 infection, inflammation in the body can invade the brain and result in microvasculature changes consistent with that of a neurodegenerative brain