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Introduction Growth hormone (GH) is an essential regulator of growth, body composition and fuel metabolism and, consequently, GH secretion is under the feedback control of numerous nutritional and endocrine mediators

While synthetic GLP-1 receptor agonists (RAs) like semaglutide and tirzepatide dominate clinical use, plant-derived GLP-1 modulators present a promising alternative due to their natural origin, diverse mechanisms, and potential for reduced side effects

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In 2014, the US Food and Drug Administration approved the first glucagon-like peptide-1 (GLP-1) receptor agonist product, liraglutide injection, for obesity treatment

Key Findings: -45 (91.8%) of 49 websites prescribed a GLP-1RA

Allulose is not a GLP-1 agonist, but emerging research suggests it may modulate glucose metabolism and GLP-1 secretion in ways that merit clinical attention