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Finally, the combination of a GLP-1 receptor agonist and amylin agonism by cagrilintide/semaglutide is currently under investigation (Table 1)

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Their diabetic control and cardiometabolic risk factors like blood pressure and cholesterol also tend to revert to their previous state. Dr Tan highlights the Surmount-4 clinical trial that looked at the issue of weight regain after treatment with tirzepatide