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Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, Phase 2 trial

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For example, the Anti-Amyloid Treatment in Asymptomatic Alzheimers Disease (A4) trial screened potential participants and selected at-risk individuals for the trial population based on evidence of brain amyloid accumulation on PET imaging and cognitive status (Sperling et al., 2014)

Participants saw rapid initial loss through weeks 4 to 12, peak velocity between weeks 12 and 24 (roughly 1.8 pounds per week), gradual slowing between weeks 24 and 36, and a plateau or near-plateau by weeks 44 to 48

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