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J Clin Transl Sci, 7(1), e184

A: It is the first triple agonist (GLP-1 + GIP + Glucagon) studied in Phase 3 trials

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They bind GLP-1 receptors, stimulating insulin release, reducing glucagon secretion, and promoting fullness, all of which help regulate blood sugar and support weight loss

However, significant variations in control types (placebo, MET, or intensive lifestyle), concomitant medications, and follow-up windows mean that a robust head-to-head ranking of strategies is still lacking

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