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Some preliminary evidence suggests changes in food preferences might play a role in weight loss, but its not clear how much such changes contribute to that result compared with the medications effect on satiety

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Lilly's triple agonist retatrutide delivered weight loss of up to 28.7% in adults with obesity

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This swelling can press on nerves, including the sciatic nerve, causing sharp or shooting pain down the back and legs (sciatica)

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