glp 1 agonist news Science's 2023 Breakthrough: GLP-1 Agonists Show Promise Against Obesity-Associated Disease Study finds GLP-1 receptor agonists

Metformin has a known GI effect that tends toward looser stools in some patients, which can partially offset GLP-1-related constipation

It was traditionally believed that gastrointestinal symptoms were a direct outcome of a delay in gastric emptying

The cells that made glucagon-like material were called L-cells

Insulin is co-crystalized with Zn 2+ in the secretory granules of the -cells [590,591] and Zn 2+ is co-secreted with insulin under conditions of hyperglycemia [592,593]

Governments looking to reduce the costs of healthcare and boost economic productivity also need to tread carefully when encouraging the use of GLP-1 drugs in people with obesity without addressing the wider socio-economic challenges patients face as well as the problems posed by the rise in ultra-processed food and poor provision of physical exercise facilities

Since GLP-1R has been localized by immunocytochemistry in mouse aortic smooth muscle cells, endothelial cells, monocytes, and macrophages, both direct and indirect actions of GLP-1 may contribute to the potential reduction of atherogenesis