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In vivo: In ob/ob mice, administration of Exendin-4 (10 g/kg or 20 g/kg) improved insulin sensitivity and significantly reduced serum glucose and hepatic steatosis

Patients on long-term therapy may have a slightly longer washout period

Sadri responded to FDA's Form 483 to explain the discrepancies, including delayed activation of the clinical trial site and shortening of the enrollment period, and said he would update the standard operating procedures

Siciliano, M

Karmaus PWF, Wagner JG, Harkema JR, Kaminski NE, Kaplan BLF
