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observed two distinct populations of alpha-cells with similar proglucagon expression but differential expression of proliferation-associated genes (e.g., TOP2A , MKI67 , CENPF , BIRC5 , and CDK1 ), suggesting that one of these subpopulations, albeit the smaller subpopulation, of alpha-cells may constitute proliferating alpha-cells (71)

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Additional hypotheses include the rapid correction of glycemia following GLP-1 RA administration, similar to the exacerbation of DR, as well as long-term effects of prior hyperglycemia via persistent changes in endothelial gene expression, often referred to as glucose memory [198,199]

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