comparing cardiovascular and kidney outcomes with tirzepatide vs. glp-1 agonists An Observational Study of of vs Glucagon-Like Peptide-1 Receptor GLP-1 receptor agonists and next-generation
Description
Diabetes Obes Metab (2016) 18(6):5819
Naunyn-Schmiede 'S
Individual response guides these decisions
van Buuren, S
In fact, the GLP- 1 receptor-cAMP-PKA axis stimulates the growth of beta cells by activating the transducer of regulated cAMP response element-binding protein (CREB) (TORC2) and the expression of the CREB and insulin receptor substrate 2 genes [57] Additionally, by boosting bcl- 2 activity and blocking the proapoptotic Bax, activated CREB also supports beta cell survival [58]
Early data suggest even greater weight loss and metabolic benefits
