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According to NICE guidance (NG28), patients on GLP-1 receptor agonists should be reviewed regularly, with continuation based on specific HbA1c reduction and weight loss targets at around 6 months of treatment

The evidence, however, does not strongly support this approach

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Its understanding who will see improvements in blood sugar, heart health, liver disease and kidney function. Long-term questions still remain Hardaway says GLP-1 drugs are essentially supercharged versions of a naturally occurring hormone, and decades of neuroscience research show that receptors can adapt to prolonged stimulation

In the UK, medical screening is essential before considering any peptide-based treatment

Systematic rotation across approved sites (at least 2-3 cm apart within a site, then switching to a different anatomical location) minimizes this risk