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PKA-mediated phosphorylation of the human KATP channel: separate roles of Kir6.2 and SUR1 subunit phosphorylation

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In May 2024, Roches dual GLP-1/GIP receptor agonist CT-388 produced positive findings treating obesity and type 2 diabetes in a Phase Ib clinical trial
Beyond its established roles in enhancing insulin secretion, inhibiting glucagon release, and promoting satiety, GLP-1 exerts pleiotropic immune modulatory and anti-inflammatory effects in multiple systems such as the renal, cardiovascular, and central nervous systems [15]

Henceforth, researchers devised numerous strategies for drug development, mainly by evading the enzymatic degradation of bioactive GLP-1 peptide by DPP-4