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Retrieved 18 August 2025
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It mostly does, but there are important nuances

While semaglutide activates GLP-1 receptors alone, tirzepatide activates both GLP-1 and GIP pathways simultaneously, a mechanism that has shown measurably stronger weight reduction in clinical trials
Someone on 2.4mg semaglutide (the maximum weight loss dose) might expect to start tirzepatide at 10mg or higher