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This stapling technique involves reacting linear i,i+7 diazido peptides (i.e., containing two azido amino acids that are seven residues apart) with dialkynyl stapling linkers under Cu(I) catalysis

The gastrointestinal side effects may also prove more problematic for older adults, particularly those with existing digestive conditions or those taking multiple medications that interact with gut function

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Tirzepatide activates GLP-1 and GIP receptors that influence blood vessel function, fluid balance, and brain signaling

However, excess added sugar can lead to obesity, heart disease, and diabetes

Individual responses vary widely, underscoring the need for ongoing provider monitoring throughout treatment