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For perspective, prior to 2023, the top-selling drugs were largely immunology or oncology biologics (like Humira, Keytruda, Eliquis), but by mid-2024, the list transformed GLP-1 agonists entered the top ranks

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TNF- , tumor necrosis factor-

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This hormone activates GLP-1 receptors in the enteric nervous system and through vagal pathways that influence digestive function

A recent meta-analysis demonstrated that SGLT2 inhibitors and glucagon-like 1 receptor agonists (GLP-1RAs) have favorable effects on the cardiorenal outcomes in type 2 diabetes (T2D) (Giugliano et al., 2019