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NICE NG28 recommends considering an SGLT2 inhibitor as the preferred option in adults with type 2 diabetes and chronic kidney disease or heart failure, unless contraindicated or not tolerated

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[DOI] [PMC free article] [PubMed] 102.Wang Y, Song X, Zhuang L, Lang H, Yu L, Yan X, et al

The fact that tirzepatide at therapeutic doses did not push calcitonin into concerning ranges provides direct biochemical evidence against the rodent-to-human translation of C-cell risk

Serious adverse events Both compounds have been associated with rare but serious adverse events in clinical trials
