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Conclusion GLP-1 therapies represent a significant advancement in managing obesity and its associated cardiovascular risks

These signaling properties are expected to lead to strong glycemic control, significant weight loss and good tolerability

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( 10.1007/s12325-023-02750-4) [DOI] [PMC free article] [PubMed] [Google Scholar] Ferdinand KC White WB Calhoun DA Lonn EM Sager PT Brunelle R Jiang HH Threlkeld RJ Robertson KE & Geiger MJ

(BMI) 30 6 GLP-1 ,

reported that overexpression of the transcription factor c-Jun in CAR-T cells reshapes gene regulatory networks and counteracts exhaustion-associated transcriptional programs, delaying terminal differentiation and preserving memory-like features, which ultimately enhances CAR-T cell persistence within the TME